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1

Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity

Helen Y. Chen, Kevin D. Dykstra, Elizabeth T. Birzin, Katalin Frisch, Wanda Chan, Yi T. Yang, Ralph T. Mosley, Frank DiNinno, Susan P. Rohrer, James M. Schaeffer, Milton L. Hammond

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 263 KB

english, 2004

2

A stereocontrolled total synthesis of (.+-.)-hirsutic acid C

Trost, Barry M., Shuey, Charles D., DiNinno, Frank

Journal:

Journal of the American Chemical Society

Year:

1979

Language:

english

File:

PDF, 300 KB

english, 1979

3

ChemInform Abstract: A Facile Synthesis of 3-Aryl-substituted-benzothiophenes via a Lewis Acid Mediated Cyclization of 2-Arylthio-acetophenones.

Seongkon Kim, Jane Yang, Frank DiNinno

Journal:

Year:

1999

File:

PDF, 33 KB

1999

4

ChemInform Abstract: The Synthesis and Anti-MRSA Activity of Amidinium-Substituted 2-Dibenzofuranylcarbapenems.

Joanne B. Laub, Mark L. Greenlee, Frank DiNinno, Joann L. Huber, Jon G. Sundelof

Journal:

Year:

2000

File:

PDF, 29 KB

2000

5

ChemInform Abstract: 2-Naphthylcarbapenems: Broad Spectrum Antibiotics with Enhanced Potency Against MRSA.

Mark L. Greenlee, Frank DiNinno, Jeffrey J. Herrmann, Cynthia Jaworsky, David A. Muthard, Thomas N. Salzmann

Journal:

Year:

2000

File:

PDF, 32 KB

2000

6

ChemInform Abstract: Dicationic 2-Fluorenonylcarbapenems: Potent anti-MRS Agents with Improved Solubility and Pharmacokinetic Properties.

Mark L. Greenlee, Joanne B. Laub, Gregory P. Rouen, Frank DiNinno, Milton L. Hammond, Joann L. Huber, Jon G. Sundelof, Gail G. Hammond

Journal:

Year:

2000

File:

PDF, 34 KB

2000

7

Dehydrative Reduction: A Highly Diastereoselective Synthesis of syn-Bisaryl(or Heteroaryl) Dihydrobenzoxathiins and Benzodioxane.

Seongkon Kim, Jane Y. Wu, Helen Y. Chen, Frank DiNinno

Journal:

Year:

2003

File:

PDF, 231 KB

2003

8

A highly efficient method for the preparation of 2-aryl substituted carbapenems exploiting a Pd(0) mediated cross-coupling reaction

Thomas A. Rano, Mark L. Greenlee, Frank P. DiNinno

Journal:

Tetrahedron Letters

Year:

1990

Language:

english

File:

PDF, 274 KB

english, 1990

9

Estrogen receptor ligands. Part 11: Synthesis and activity of isochromans and isothiochromans

Jian Liu, Elizabeth T. Birzin, Wanda Chan, Yi Tien Yang, Lee-Yuh Pai, Carolyn DaSilva, Edward C. Hayes, Ralph T. Mosley, Frank DiNinno, Susan P. Rohrer, James M. Schaeffer, Milton L. Hammond

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 320 KB

english, 2005

10

Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERα

Kevin D. Dykstra, Liangqin Guo, Elizabeth T. Birzin, Wanda Chan, Yi Tien Yang, Edward C. Hayes, Carolyn A. DaSilva, Lee-Yuh Pai, Ralph T. Mosley, Bryan Kraker, Paula M.D. Fitzgerald, Frank DiNinno, Su

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 841 KB

english, 2007

11

4,7-Dichloro benzothien-2-yl sulfonylaminomethyl boronic acid: First boronic acid-derived beta-lactamase inhibitor with class A, C, and D activity

Qiang Tan, Aimie M. Ogawa, Ronald E. Painter, Young-Whan Park, Katherine Young, Frank P. DiNinno

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 390 KB

english, 2010

12

The synthesis and antibacterial activity of 2-carbolinyl-carbapenems: potent anti-MRSA/MRCNS agents

Laura C. Meurer, Ravindra N. Guthikonda, Joann L. Huber, Frank DiNinno

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 362 KB

english, 1995

13

The discovery and synthesis of 2-biphenylcarbapenems active against methicillin resistant staphylococci

Frank DiNinno, David A. Muthard, Thomas N. Salzmann, Joann Huber, Jean Kahan, Helmut Kropp

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 183 KB

english, 1995

14

Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs

Helen Y. Chen, Seongkon Kim, Jane Y. Wu, Elizabeth T. Birzin, Wanda Chan, Yi Tien Yang, Johanna Dahllund, Frank DiNinno, Susan P. Rohrer, James M. Schaeffer, Milton L. Hammond

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 261 KB

english, 2004

15

Estrogen receptor ligands. Part 4: The SAR of the syn-dihydrobenzoxathiin SERAMs

Seongkon Kim, Jane Wu, Helen Y. Chen, Elizabeth T. Birzin, Wanda Chan, Yi Tien Yang, Lawrence Colwell, Susan Li, Johanna Dahllund, Frank DiNinno, Susan P. Rohrer, James M. Schaeffer, Milton L. Hammond

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 271 KB

english, 2004

16

Estrogen receptor ligands. Part 5: The SAR of dihydrobenzoxathiins containing modified basic side chains

Qiang Tan, Elizabeth T Birzin, Wanda Chan, Yi Tien Yang, Lee-Yuh Pai, Edward C Hayes, Carolyn A DaSilva, Frank DiNinno, Susan P Rohrer, James M Schaeffer, Milton L Hammond

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 298 KB

english, 2004

17

Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains

Timothy A Blizzard, Frank DiNinno, Jerry D Morgan II, Jane Y Wu, Helen Y Chen, Seongkon Kim, Wanda Chan, Elizabeth T Birzin, Yi Tien Yang, Lee-Yuh Pai, Zhoupeng Zhang, Edward C Hayes, Carolyn A DaSilv

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 263 KB

english, 2004

18

Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers

Timothy A. Blizzard, Frank DiNinno, Jerry D. Morgan II, Helen Y. Chen, Jane Y. Wu, Seongkon Kim, Wanda Chan, Elizabeth T. Birzin, Yi Tien Yang, Lee-Yuh Pai, Paula M.D. Fitzgerald, Nandini Sharma, Ying

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 409 KB

english, 2005

19

Estrogen receptor ligands. Part 13: Dihydrobenzoxathiin SERAMs with an optimized antagonist side chain

Timothy A. Blizzard, Frank DiNinno, Helen Y. Chen, Seongkon Kim, Jane Y. Wu, Wanda Chan, Elizabeth T. Birzin, Yi Tien Yang, Lee-Yuh Pai, Edward C. Hayes, Carolyn A. DaSilva, Susan P. Rohrer, James M.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 162 KB

english, 2005

20

Estrogen receptor ligands. Part 14: Application of novel antagonist side chains to existing platforms

Timothy A. Blizzard, Jerry D. Morgan II, Wanda Chan, Elizabeth T. Birzin, Lee-Yuh Pai, Edward C. Hayes, Carolyn A. DaSilva, Ralph T. Mosley, Yi Tien Yang, Susan P. Rohrer, Frank DiNinno, Milton L. Ham

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 176 KB

english, 2005

21

Thiophenyl oxime-derived phosphonates as nano-molar class C beta-lactamase inhibitors reducing MIC of imipenem against Pseudomonas aeruginosa and Acinetobacter baumannii

Qiang Tan, Aimie M. Ogawa, Susan L. Raghoobar, Douglas Wisniewski, Lawrence Colwell, Young-Whan Park, Katherine Young, Jeffrey D. Hermes, Frank P. DiNinno, Milton L. Hammond

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 513 KB

english, 2011

22

Intramolecular condensations of N-(5-oxohexyl) nitrogen heterocycles; a new annulation procedure

R.Marshall Wilson, Frank DiNinno Jr.

Journal:

Tetrahedron Letters

Year:

1970

Language:

english

File:

PDF, 223 KB

english, 1970

23

A convenient synthesis of racemic 6-hydroxyethyl-2-alkylthio-substituted penems

Frank DiNinno, David A. Muthard, Ronald W. Ratcliffe, Burton G. Christensen

Journal:

Tetrahedron Letters

Year:

1982

Language:

english

File:

PDF, 221 KB

english, 1982

24

A novel intramolecular condensation of N-(2-cyanomethyltryptophyl)pyridinium tosylates

Frank DiNinno Jr., William L. Heckle Jr., Don K. Rehse, R.Marshall Wilson

Journal:

Tetrahedron Letters

Year:

1972

Language:

english

File:

PDF, 235 KB

english, 1972

25

A facile synthesis of 3-aryl-substituted-benzothiophenes via a lewis acid mediated cyclization of 2-arylthio-acetophenones

Seongkon Kim, Jane Yang, Frank DiNinno

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 191 KB

english, 1999

26

2-Naphthylcarbapenems: Broad spectrum antibiotics with enhanced potency against MRSA

Mark L. Greenlee, Frank DiNinno, Jeffrey J. Herrmann, Cynthia Jaworsky, David A. Muthard, Thomas N. Salzmann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 243 KB

english, 1999

27

The synthesis and anti-MRSA activity of amidinium-substituted 2-dibenzofuranylcarbapenems

Joanne B. Laub, Mark L. Greenlee, Frank DiNinno, Joann L. Huber, Jon G. Sundelof

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 222 KB

english, 1999

28

Dicationic 2-fluorenonylcarbapenems: Potent anti-MRS agents with improved solubility and pharmacokinetic properties

Mark L. Greenlee, Joanne B. Laub, Gregory P. Rouen, Frank DiNinno, Milton L. Hammond, Joann L. Huber, Jon G. Sundelof, Gail G. Hammond

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 374 KB

english, 1999

29

Estrogen receptor ligands. Part 6: Synthesis and binding affinity of dihydrobenzodithiins

Qiang Tan, Elizabeth T Birzin, Wanda Chan, Yi Tien Yang, Lee-Yuh Pai, Edward C Hayes, Carolyn A DaSilva, Frank DiNinno, Susan P Rohrer, James M Schaeffer, Milton L Hammond

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 251 KB

english, 2004

30

Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains

Timothy A Blizzard, Frank DiNinno, Jerry D Morgan II, Helen Y Chen, Jane Y Wu, Candido Gude, Seongkon Kim, Wanda Chan, Elizabeth T Birzin, Yi Tien Yang, Lee-Yuh Pai, Zhoupeng Zhang, Edward C Hayes, Ca

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 271 KB

english, 2004

31

An efficient synthesis of 2-substituted-thio-6-hydroxyethyl-penem-3-carboxylic acids via 2-thioxopenams

W.J. Leanza, Frank DiNinno, David A. Muthard, R.R. Wilkening, Kenneth J. Wildonger, R.W. Ratcliffe, B.G. Christensen

Journal:

Year:

1983

Language:

english

File:

PDF, 987 KB

english, 1983

32

The syntheses of functionalized 2-alkenyl and alkynyl-1-β-methyl-carbapenems via the stille cross-coupling reaction

Kevin D. Dykstra, Frank DiNinno

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 224 KB

english, 1998

33

The synthesis and antibacterial activity of 2-para-quarternary ammoniomethylphenyl-carbapenems.

Frank DiNinno, David A. Muthard, Thomas N. Salzmann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 420 KB

english, 1993

34

Agonist-like SERM effects on ERα-mediated repression of MMP1 promoter activity predict in vivo effects on bone and uterus

Angela Scafonas, Alfred A. Reszka, Donald B. Kimmel, Xiaoli Shirley Hou, Qin Su, Elizabeth T. Birzin, Seongkon Kim, Helen Y. Chen, Qiang Tan, Susan P. Roher, Frank Dininno, Milton L. Hammond, Gideon A

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2008

Language:

english

File:

PDF, 841 KB

english, 2008

35

Dehydrative Reduction: A Highly Diastereoselective Synthesis of syn -Bisaryl(or Heteroaryl) Dihydrobenzoxathiins and Benzodioxane

Kim, Seongkon, Wu, Jane Y., Chen, Helen Y., DiNinno, Frank

Journal:

Organic Letters

Year:

2003

Language:

english

File:

PDF, 82 KB

english, 2003

36

Cytochrome P450 3A4-Mediated Bioactivation of Raloxifene: Irreversible Enzyme Inhibition and Thiol Adduct Formation

Chen, Qing, Ngui, Jason S., Doss, George A., Wang, Regina W., Cai, Xiaoxin, DiNinno, Frank P., Blizzard, Timothy A., Hammond, Milton L., Stearns, Ralph A., Evans, David C., Baillie, Thomas A., Tang, W

Journal:

Chemical Research in Toxicology

Year:

2002

Language:

english

File:

PDF, 104 KB

english, 2002

37

Estrogen Receptor Ligands. 12. Synthesis of the Major Metabolites of an ERα-Selective, Dihydrobenzoxathiin Antagonist for Osteoporosis

Kim, Seongkon, Wu, Jane Y., Zhang, Zhoupeng, Tang, Wei, Doss, George A., Dean, Brian J., DiNinno, Frank, Hammond, Milton L.

Journal:

Organic Letters

Year:

2005

Language:

english

File:

PDF, 105 KB

english, 2005

38

In Vitro Bioactivation of Dihydrobenzoxathiin Selective Estrogen Receptor Modulators by Cytochrome P450 3A4 in Human Liver Microsomes: Formation of Reactive Iminium and Quinone Type Metabolites

Zhang, Zhoupeng, Chen, Qing, Li, Ying, Doss, George A., Dean, Brian J., Ngui, Jason S., Silva Elipe, Maria, Kim, Seongkon, Wu, Jane Y., DiNinno, Frank, Hammond, Milton L., Stearns, Ralph A., Evans, Da

Journal:

Chemical Research in Toxicology

Year:

2005

Language:

english

File:

PDF, 253 KB

english, 2005

39

Aldol condensations of regiospecific penicillanate and cephalosporanate enolates. Hydroxyethylation at C-6 and C-7

DiNinno, Frank, Beattie, Thomas R., Christensen, B. G.

Journal:

Journal of Organic Chemistry

Year:

1977

Language:

english

File:

PDF, 819 KB

english, 1977

40

Additions and Corrections - A Stereocontrolled Total Synthesis of (±)-Hirsutic Acid C

Trost, Barry, Shuey, Charles, DiNinno, Jr., Frank

Journal:

Journal of the American Chemical Society

Year:

1979

Language:

english

File:

PDF, 126 KB

english, 1979

41

Penems. 1. Penem formation via a novel oxidative addition process mediated by copper(I)

DiNinno, Frank, Linek, Ernest V., Christensen, B. G.

Journal:

Journal of the American Chemical Society

Year:

1979

Language:

english

File:

PDF, 313 KB

english, 1979

42

A facile synthesis of #b-thioxo esters from .beta.-enamino esters

DiNinno, Frank, Linek, Ernest V.

Journal:

Journal of Organic Chemistry

Year:

1979

Language:

english

File:

PDF, 427 KB

english, 1979

43

3-Oxo-6-thia-2-azabicyclo[2.2.0]hexanes: novel .beta.-lactams derived from penams

Journal:

Journal of the American Chemical Society

Year:

1978

Language:

english

File:

PDF, 277 KB

english, 1978

44

Estrogen Receptor Ligands. Part 15: Synthesis of Benzothiopyran-based Selective Estrogen Receptor Alpha Modulators (SERAM)

Kim, Seongkon, DiNinno, Frank, T. Birzin, Elizabeth, Chan, Wanda, Tien Yang, Yi, L. Hammond, Milton

Journal:

Year:

2006

Language:

english

File:

PDF, 185 KB

english, 2006